Palmatine, a protoberberine alkaloid, inhibits both Ca2+ - and cAMP-activated Cl− secretion in isolated rat distal colon
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چکیده
منابع مشابه
Cyclic AMP-induced K+ secretion occurs independently of Cl- secretion in rat distal colon.
cAMP induces both active Cl(-) and active K(+) secretion in mammalian colon. It is generally assumed that a mechanism for K(+) exit is essential to maintain cells in the hyperpolarized state, thus favoring a sustained Cl(-) secretion. Both Kcnn4c and Kcnma1 channels are located in colon, and this study addressed the questions of whether Kcnn4c and/or Kcnma1 channels mediate cAMP-induced K(+) se...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2008
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0707684